In the video - How Proteins Get Into Peroxisomes | Biology Explained - I look at how the cell targets proteins to the peroxisomes.
Peroxisomes are involved in fatty acid oxidation and detoxification. The import of proteins into the peroxisomes relies on a short SKL motif at the C-terminal of the protein, which acts as an address.
The SKL motif binds to the PTS1R receptor in the cytosol, which then interacts with the Pex14P receptor on the peroxisome membrane. The protein can either be imported with or without the receptor entering the peroxisome.
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