New Video Posted: Understanding Endosomes: The Cell's Sorting House | Quick Science Explanation

In my video on endosomes - Understanding Endosomes: The Cell's Sorting House | Quick Science Explanation - I look at the role of the endosomal system in cells.

Endosomes are cellular compartments that sort and traffic proteins from the Golgi apparatus and the plasma membrane. They are formed by vesicle fusion and are divided into three types

• Early endosomes - receive proteins and decide their next destination
• Recycling endosomes - return proteins to the plasma membrane either immediately (constitutive pathway) or based on signals (regulated pathway).
• Late endosomes - forward proteins to lysosomes or back to the Golgi.

The endosomal system relies on specific signals on proteins to direct their correct routing, ensuring efficient cellular function.

If you would like to say thanks for the video, then please feel free to buy me a coffee at https://www.buymeacoffee.com/drnickm

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New Video Posted: How Proteins Get Into Peroxisomes | Biology Explained

In the video - How Proteins Get Into Peroxisomes | Biology Explained - I look at how the cell targets proteins to the peroxisomes.

Peroxisomes are involved in fatty acid oxidation and detoxification. The import of proteins into the peroxisomes relies on a short SKL motif at the C-terminal of the protein, which acts as an address. 

The SKL motif binds to the PTS1R receptor in the cytosol, which then interacts with the Pex14P receptor on the peroxisome membrane. The protein can either be imported with or without the receptor entering the peroxisome.

If you would like to say thanks for the video, then please feel free to buy me a coffee at https://www.buymeacoffee.com/drnickm

Blog Bonus: Free information sheet summarising the video and defining the key terms - download.

New Video Posted: Understanding Protein Sorting: Cellular Transport Mechanisms Explained

Protein sorting involves directing proteins, which originate on ribosomes in the cytosol, to their appropriate cellular locations using specific amino acid sequences known as sorting signals. These sorting signals function like postcodes, guiding proteins to various organelles or membranes within the cell, such as the nucleus, peroxisomes, or the endoplasmic reticulum. The cell employs different types of transport mechanisms—gated, transmembrane, and vesicular—to move proteins to their correct destinations, ensuring proper cellular function.

If you would like to say thanks for the video, then please feel free to buy me a coffee at https://www.buymeacoffee.com/drnickm

Blog Bonus: Free information sheet summarising the video and defining the key terms - download.