Monday 10 June 2024

New Video Posted: Understanding Vesicle Trafficking and the SNARE Hypothesis

In this video, Understanding Vesicle Trafficking and the SNARE Hypothesis, I look at the SNARE hypothesis and how it helps the targetting of vesicles to the correct membrane.


Vesicle trafficking is a crucial cellular process where vesicles transport materials to specific organelles or membranes. This process involves the SNARE hypothesis, where vesicles have vesicle SNAREs (vSNAREs) and target membranes have target SNAREs (tSNAREs). The vSNAREs and tSNAREs recognise each other, ensuring that vesicles dock at the correct membranes.

However, the SNARE proteins are promiscuous and can bind with multiple partners, posing challenges for precise docking. To address this, cells use Tether proteins, which operate over greater distances and add an additional layer of specificity. Tether proteins help vesicles recognise their target membranes, while SNAREs facilitate the fusion process.

This combined mechanism ensures accurate vesicle targeting and fusion, which is regulated by a GTP timer that coordinates the events. 

If you would like to say thanks for the video, then please feel free to buy me a coffee at

Blog Bonus: Free information sheet summarising the video and defining the key terms - download.

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