Nick's Teaching Blog: GPCR

Tuesday 16 October 2012

The structure of a G-protein coupled receptor is often shown as:

Screen Shot 2012 10 16 at 20 58 21

However, the crystal structure of bovine rhodopsin shows that the seven transmembrane-spanning domains actually form a tight core

J. Mol. Biol. (2004) 342, 571–583 https://www.rcsb.org/structure/1U19

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I have been asked for access to a number of the movies I used in the lectures.

The following animation shows the proposed movements of transmembrane spanning domains 3 and 6 for rhodopsin and β2 adrenergic receptors.

It should be noted that other GPCRs may use different methods.

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