Bovine Rhodopsin

The structure of a G-protein coupled receptor is often shown as:


However, the crystal structure of bovine rhodopsin shows that the seven transmembrane-spanning domains actually form a tight core


J. Mol. Biol. (2004) 342, 571–583 https://www.rcsb.org/structure/1U19

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Additional Resources

• 📗 - Biochemistry (Stryer) (affiliate link)
• 📗 - Principles of Biochemistry (Lehninger) (affiliate link)

3d Structure - β2AR-T4L

The structure of a G-protein coupled receptor is often shown as:


Which shows a receptor with the N-terminal outside the cell, seven transmembrane-spanning domains, 3 exoloops, 4 cytoloops and a C terminal inside the cell.

However, it is actually more compact, with the seven transmembrane spanning domains forming a tight core.


Lower part = T4-lysozyme in place of cyto 3 Small green molecules = cholesterol; can just make out bound ligand in pocket
Science. 2007 318(5854): 1258–1265. https://www.rcsb.org/structure/2RH1

If you would like to support my blogging efforts, then please feel free to buy me a coffee at https://www.buymeacoffee.com/drnickm

Additional Resources

• 📗 - Biochemistry (Stryer) (affiliate link)
• 📗 - Principles of Biochemistry (Lehninger) (affiliate link)