The movie below shows the 3d structure of a guanosine diphosphate (GDP) bound G protein alpha-subunit.
The small green molecule in the middle is the bound GDP.
https://www.rcsb.org/structure/1TAG
If you would like to support my blogging efforts, then please feel free to buy me a coffee at https://www.buymeacoffee.com/drnickm
If you would like to support my blogging efforts, then please feel free to buy me a coffee at https://www.buymeacoffee.com/drnickm
If you would like to support my blogging efforts, then please feel free to buy me a coffee at https://www.buymeacoffee.com/drnickm
The following animation shows αGs interacting with adenylyl cyclase.
The animation is also available as a slightly larger video....
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I have been asked for access to a number of the movies I used in the lectures.
The following animation shows the proposed movements of transmembrane spanning domains 3 and 6 for rhodopsin and β2 adrenergic receptors.
It should be noted that other GPCRs may use different methods.
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I have just read a really interesting paper in Science1, which has a very good write-up in the New York Times (New York Times: "To Really Learn, Quit Studying and Take a Test" - link) on how to study.
I am not going to discuss the findings of the paper here, but instead, I will just mention the major findings of the work.
Basically, Karpicke and Janell1 looked at how students learn. They have used a scientific approach to look at this with some carefully designed experiments. The authors looked at:
The findings, put in simple terms (as judged by testing the students a week after carrying out the original exercise), was that method 4 and 5 produced the best results. That is, read the text, and then test yourself.
I strongly recommend reading the write-up in the New York Times (link) and then tackling the original paper at Science.
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Reference:
Today I started blogging over at Scitable (Nature Education). The new blog can be found here.
So, why two blogs?
Well, the two blogs have two different functions:
This Blog
The function of this blog is to directly serve my teaching.
I will continue to post material here that is connected with the courses I deliver, and it will also continue to host the 'science' tweets (tweets that link to papers and articles of interest) I post.
The Scitable Blog
The Scitable Blog will be used for posts connected to the use of technology in teaching and learning.
In the Scitable Blog I plan to write about how technology can be used to teach the biosciences, and how students can use technology to help with their studies. The Scitable Blog will contain posts that are (hopefully) of use to both lecturers and students.
If you would like to support my blogging efforts, then please feel free to buy me a coffee at https://www.buymeacoffee.com/drnickm
