Tuesday 16 October 2012

3d Structure - β2AR-T4L

The structure of a G-protein coupled receptor is often shown as:

Screen Shot 2012 10 16 at 20 58 21

Which shows a receptor with the N-terminal outside the cell, seven transmembrane-spanning domains, 3 exoloops, 4 cytoloops and a C terminal inside the cell.

However, it is actually more compact, with the seven transmembrane spanning domains forming a tight core.

Beta2AR

Lower part = T4-lysozyme in place of cyto 3 Small green molecules = cholesterol; can just make out bound ligand in pocket
Science. 2007 318(5854): 1258–1265. https://www.rcsb.org/structure/2RH1

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