Wednesday 17 April 2024

New video posted: DNA replication: How does a cell make a copy of its DNA?

Have you ever been curious about the precision with which DNA is replicated in our cells, or why human pregnancies don't extend to an unimaginable sixteen years?

In my latest video, I examine the process of DNA replication. First, I explore how the DNA double helix is unwound by DNA helicase and how the unwound DNA is stabilised by Single Stranded Binding Proteins. I look at the replication fork and how DNA polymerases copy the DNA strands.

I also cover the formation of Okazaki fragments—short sequences of DNA synthesised on the lagging strand—and how DNA ligase is responsible for stitching these fragments together. Additionally, the video highlights the importance of topoisomerase in preventing the DNA from becoming overly twisted and tangled during replication.

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Blog Bonus: Free information sheet summarising the video and defining the key terms - download.

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