Tuesday, 16 October 2012

BGM3001:BMS3011 - lecture movies - 3d Structure - β2AR-T4L

The structure of a G-protein coupled receptor is often shown as:

Screen Shot 2012 10 16 at 20 58 21

Which shows a receptor with the N-terminal outside the cell, seven transmembrane spanning domains, 3 exoloops, 4 cytoloops and a C terminal inside the cell.
However, it is actually more compact with the seven transmembrane spanning domains forming a tight core.

Beta2AR

Lower part = T4-lysozyme in place of cyto 3 Small green molecules = cholesterol; can just make out bound ligand in pocket
Science. 2007 318(5854): 1258–1265. http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2RH1